Lab of Combinatorial Genetics & Synthetic Biology @ HKU

News

16 Aug 2024

Lunch celebrations for all the PhD graduates in our lab.
Well done Becky, Bei, Charles and John. All the best for your future endeavour.


05 Aug 2024

SBMS Summer Academy 2024
Many thanks to everyone helping out in the SBMS Summer Academy 2024 events.


05 Jul 2024

Prof. Wong gave a talk at the Hoi Ping Chamber of Commerce Secondary School (HPCCSS) for public science talk through the A+ scheme


27 Jun 2024

Prof. Wong shared his opinion on new technologies and applications of CRISPR in Metro Broadcast
episode link


25 Jun 2024

Showcase in the Hong Kong Association of Clinicians in Training (HKACT) Research Crashcourse Workshop
We are invited to provide a wet-lab skill workshop for housemen and medical students in HKU and CUHK so as to provide them an opportunity to acquire some research skills and experiences, as well as understand the importance of research in the medical career.


16 May 2024

Presenting in the Asia Summit on Global Health 2024
We are invited to exhibit at the Asia Summit on Global Health (ASGH) on 16 and 17May, 2024. This collaborative initiative by the Government of the Hong Kong Special Administrative Region and the Hong Kong Trade Development Council (HKTDC) aims to foster innovation and collaboration in the field of global health.


09 May 2024

Dr Wong gave his perspectives on ChatGPT for CRISPR creates new gene-editing tools
link


20 Mar 2024

Dr Wong gave a talk in the HKU-SJTU Joint Symposium to Advance Immunology
event link


08 Mar 2024

Dr Wong gave a talk in the A+ outreach event to secondary school students about CRISPR genome editing.
event link


19 Feb 2024

The acticle Accurate top protein variant discovery via low-N pick-and-validate machine learning is now available online.
Article link
Congrats to Athena, John, Nick and Fred!


22 Dec 2023

BOCHK Science and Technology Innovation Price award ceremony
Congrats to Dr. Wong as the awardee of the BOCHK Science and Technology Innovation Price 2023.
Event details


28 Nov 2023

Lab retreat 2023.


27 Nov 2023

The article Discovery of regulatory motifs in 5′ untranslated regions using interpretable multi-task learning models is now available online.
Congratulations to Weizhong and John!


23 Nov 2023

The article High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2. is now online!
Congratulations to Charles and Bei!
article link
Nature portfolio blog post


17 Nov 2023

Lab visit from the Hong Kong Laureates Forum.
Hong Kong Laureates Forum is an academic exchange event to connect current scientist and young scientists in Hong Kong and around the world in various disciplines in science and technology.


06 Nov 2023

Dr Wong talks about applying AI on CRISPR engineering in the news.
News article published in AM730:


03 Nov 2023

Lucas has been awarded the Mr & Mrs SH Wong Foundation Scholarship for MRes[Med] 2023-24.
Well done Lucas!


19 Oct 2023

Lucas has been granted the Research Internship Award under the Undergraduate Research Fellowship Programme (URFP)
Well done Lucas!


07 Aug 2023

HKU Biomedical Sciences Summer Academy 2023
Many thanks to our lab tour guides John, Bei and Charmaine, and others helping out in the event. It was a collective effort to engage 35 students, as well as their teachers, from 7 different local secondary schools in this research experience.


11 Jul 2023

A day @ BME
Many thanks to our lab tour guides John, Charles, Bei and Jessie at the A day @ BME event!


04 Jul 2023

The Base-editors profiling platform developed by John is reported in local news outlets.
News coverage: 香港大學開發全球首個篩選精確基因編輯工具平台 in TVB news, 信報, 大公報, 文匯報, 東方日報, Labiotech, Phys.org, finance.sina.com.cn, 中国新闻网 etc.
HKU press info
Wenweipo


29 Jun 2023

John’s review Advancing CRISPR/Cas gene editing with machine learning is avaialble online.
Congratulations to John!
link


9 May 2023

John’s paper Parallel engineering and activity profiling of a base editor system is avaialble online.
Congratulations to John!
link


14 Apr 2023

Dr. Wong talked about the use of CRISPR in biomedicine in the Sci-Fi-Sci 2023 festival.
Sci-Fi-Sci is co-organised by the Hong Kong Science Museum, the Hong Kong Space Museum and the Film Programmes Office.
Programe info


22 Sep 2022

CombiSEAL featured in HKU digital art Optimizing the Future by Nick Teeple.
HKUMed launched the exhibition Medicine and Healthcare Through the Lens of Digital Art to celebrate its 135th anniversary.
Among the digital art pieces on display, CombiSEAL is featured in Optimizing the Future by Nick Teeple.
link


17 Aug 2022

What are the current bottlenecks in developing and applying CRISPR technologies?
The current prospective on CRISPR technology is now available online.
link


20 Jul 2022

Oliver’s graduation
Well done Oliver and all the best!


30 Jun 2022

The SaCas9 optimization paper has received quite a bit of media coverage.
HK01.com
Sing Tao Daily
news-medical.net
article link


17 Jun 2022

Bei’s review CRISPR screening in cancer stem cells is available online.
Well done Bei!
Review link


25 May 2022

Official Launch of InnoHK.
Dr Wong attended the official InnoHK launch ceremony.


25 Apr 2022

Dawn and Athena’s work on SaCas9 optimization is now published in Nature Communications.
Congrats to Dawn and Athena! Here is a featured blog post of the article:
Engineering CRISPR-Cas9 proteins en masse with much less experiments


10 Mar 2022

The highly accurate SaCas9 variants are featured covered in local News.
Ta Kung Pao news
Congrats to Zero and the team! The related article is published in Nucleic Acids Research.


09 Mar 2022

The highly accurate SaCas9 variants are featured in HKUMed News!
News link
Congrats to Zero and the team! The related article is published in Nucleic Acids Research.


21 Dec 2021

The lab’s finding on Combinatorial drug treatment for liver cancers is covered by local newspapers.
Headline Daily
Sing Tao Daily
Hong Kong Economic Journal
Well done, team!


15 Dec 2021

AW lab’s Christmas lunch.
The lab visited Hotel W for a nice buffet with a splendid view of the Victoria harbour. Congrats to Oliver, Yuan, Bei, Becky and John for winning the lucky draw.


08 Dec 2021

Athena’s perspective is online.
Interesting read! Article link


19 Oct 2021

Xu Feng’s paper is available online.
Well done!


01 Sept 2021

John has received the Hong Kong PhD Fellowship (HKPF) and HKU Presidential PhD Scholarship (HKU-PS).
Superb achievement, John! Have fun for your PhD!


19 Aug 2021

Our first day in InnoHK!
Very excited to start many new projects! Many Thanks to the Centre for Oncology and Immunology Limited for hosting us!


15 Jul 2021

Visting the Centre for Oncology and Immunology Limited in Science Park!
Great facilities. And an interestingg visit in InnoCell


30 Jun 2021

Becky has received the HKU University Postgraduate Fellowships (UPF).
Congrats, Becky! Great start of the PhD journey!


27 Jun 2021

Happy BME lab tour day!
Thanks everyone, for helping out. Hope you had a great time with the visitors!


29 Apr 2021

Goodbye Dawn and Cindy
Wish you all the best!!!


23 Apr 2021

Congrats to Dawn!
Nice piece of perspective writing!!
article link


26 Feb 2021

William has graduated!
Congratulations to William!


15 Jan 2021

CombiPIPE protocol published in STAR Protocols
Well done on the excellent protocol and the development of CombiPIPE. Congrats to Nick, Yukkei, Becky and Gigi!
protocol link


23 Dec 2020

Dr. Wong was interviewed in Sing Tao Daily on the development of CRISPR-Cas9 technology
news link in SBMS webpage


4 Nov 2020

YukKei and Gigi have published a book chapter “High-Throughput Protein Engineering by Massively Parallel Combinatorial Mutagenesis” in Strucutral Genomics.
Congratulations to Yukkei and Gigi!
book chapter link


30 Oct 2020

Dr. Wong was invited to talk on “Second-generation combinatorial genetics technologies for therapeutic target discovery and protein engineering” at Department of Chemical Pathology of the Chinese University of Hong Kong via Zoom.


21 Sep 2020

Dr Wong has won the NSFC Excellent Young Scientists Fund 2020.
Congratulations to Dr Wong!


1 Sep 2020

Charles has been awarded with the HKU University Postgraduate Fellowships (UPF)
Congratulations to Charles!


20 Aug 2020

Gigi, Nick, Zero, Becky, Xu Feng, Dawn, and Dr. Wong for the Faculty Outstanding Research Output Award 2020, HKUMed
Congratulations to all the awardees!


11 Aug 2020

The lab’s second paper published on Cell Reports!
Congrats to Nick, Becky, Yukkei, Zero, Gigi, Cindy, Sophia, Jieran and Jien Vei! All the hard work finally pays off!


10 July 2020

Lab Visit for Secondary School Students


3 Jan 2020

Becky has received her Mphil degree and John has received his BBiomedSc degree!
Warmest congratulations on your achievement!


15-17 Nov 2019

Invited talk at the Workshop on Enzyme Evolution for Advanced Biotechnology
Dr. Wong was invited to talk at the Workshop on Enzyme Evolution for Advanced Biotechnology in Shanghai!


12 Nov 2019

Invited talk at the 9th CUHK International Symposium on Stem Cell Biology & Regenerative Medicine
Dr. Wong was invited to talk at the 9th CUHK International Symposium on Stem Cell Biology & Regenerative Medicine.


12 Sept 2019

Dr. Wong was invited to talk at NEB’s NGS Symposium.


12 Jul 2019

Dr. Wong was invited as a keynote speaker in YASHK’s Talk Series
Dr. Wong was invited as a keynote speaker in the Talk Series on Emerging Technologies - Science, Opportunities and Challenges: Nature’s Red Pencil: Writing and Rewriting Genomes organized by the Hong Kong Young Academy of Science.


04 Jul 2019

Bye Jessie, Rachel, and Daniel
Good luck Jessie, Rachel, and Daniel moving onto their next steps!


23-27 Jun 2019

Becky at the SEED conference 2019
Becky attended the 2019 Synthetic Biology: Engineering, Evolution & Design (SEED) conference in New York City!


13 Jun 2019

The lab’s first paper got accepted by Nature Methods!


13 Jun 2019

AW lab’s Disney Retreat


19 May 2019

Invited talk at Karolinska Institutet, Sweden
Dr. Wong is invited to give a talk at Karolinska Institute in Stockholm, Sweden.


19 May 2019

Jessie got awarded at the HKU Research Colloquium for Science Undergraduate Students
Congratulations to Jessie on being awarded one of the best poster presentations in the HKU Research Colloquium for Science Undergraduate Students 2018-2019! Well done!


29 Mar - 3 Apr 2019

AACR 2019 Meeting
Nick and William went to the AACR 2019 Meeting in Atlanta, GA.


14 Dec 2018

Invited lecture @ SBMS Research Day 2018
Dr. Wong was invited to give a lecture during the School of Biomedical Science Research Day.


12 Sept 2018

Lab lunch
The lab got lunch at Japas in Kennedy Town.


28 Aug 2018

Invited talk at TRS symposium
Dr. Wong was invited to give a talk at the TRS symposium: Gastric Cancer Genomics and Beyond: Organoids, Genomics and Cell Biology.


10 Aug 2018

Croucher Summer Course in Precision Genome Engineering by CRISPR
Exciting to have the Croucher Summer Course In Precision Genome Engineering by CRISPR in Hong Kong!


8 Jun 2018

Invited talk at the 5th Macau Symposium on Biomedical Science
Dr. Wong was invited to give a talk at the 5th Macau Symposium on Biomedical Science.


23 Mar 2018

Jessie awarded the HKU Undergraduate Research Fellowship
Congratulations to Jessie on being awarded the HKU Undergraduate Research Fellowship!


30 Jan 2018

Invited talk at MWLC Scientific Symposium 2018
Dr. Wong was invited to give a talk at the MWLC Scientific Symposium 2018 held by Karolinska Institutet, HK


26 Jan 2018

Invited talk at Department of Chemical Pathology, CUHK
Dr. Wong was invited to give a talk at Department of Chemical Pathology, CUHK.


14 Aug 2017

Invited talk at City University of Hong Kong
Dr. Wong was invited to give a talk at City University of Hong Kong.


09 Jun 2017

The first international symposium organized by our lab
Engineering Complex Genetic System is the first international symposium organized by our lab! Thanks Christy for designing the conference posters and banners, and all lab members for helping to organize this exciting event!


21 Mar 2017

Invited talk at DIY Bio
Dr. Wong was invited to give a talk at DIY Bio.


11 Mar 2017

Invited lecture at the 12th International Symposium on Healthy Aging
Dr. Wong was invited to give a lecture at the 12th International Symposium on Healthy Aging.


29 Sept 2016

Invited lecture at Department of Pathology, HKU
Dr. Wong was invited to give a lecture at Department of Pathology, HKU.


18 Jun 2016

Invited lecture at the Hong Kong Society for Developmental Biology
Dr. Wong was invited to give a lecture at the Hong Kong Society for Developmental Biology.


19 May 2016

Invited lecture at SBMS Inaurgural Sympoisum 2016
Dr. Wong was invited to give a lecture at SBMS Inaurgural Sympoisum 2016.